TM
ANTI-THROMBOGENIC Mix-Ins for Catheters
DiazaMed Metal Organic Framework [MOF]
DiazaMed MOF is a biocompatible "Mix-in" material that provides indefinite anti-thrombogenic performance for all types of catheters in the blood stream.
It delivers that performance with
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No Added Thickness
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No Drugs
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No Elution
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No Biodegrading
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No Particulates
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No Flaking
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No Dissolving
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No Added Manufacturing Steps or Process Cost
MOF Delivers Long-term therapeutic action
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Remains active indefinitely
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Far exceeds performance of current commercial technologies
DiazaMed MOF is a Mix-in, not a Coating.
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Small amount is compounded directly with the polymer
The MOF continuously catalyzes a minute boundary layer of Nitric Oxide (from components in the blood) that lasts for miliseconds on
the surface of the catheter to prevent attachment and formation of thrombosis.
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Thrombis prevention and Nitric Oxide only at the surface
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No systemic effect
How Does It Work?
Dramatic Production Benefits
MOF can be processed using standard production methods:
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Extrusion
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Injection Molding
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Casting
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Other methods
Far Better Catheter Manufacturing Process
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Eliminates coating
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Reduced Cost
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Reduced Time
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Eliminates Typical Coating Inconsistency
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Eliminates Difficult and Unreliable Testing to Confirm Coating Consistency
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Simple Compounding with Polymers such as Polyurethane
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No adverse impact on physical polymer or device performance
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5 Polymers Tested
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Tests Conducted by Major Catheter Company and Colorado State University
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Simplified Production
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No Additional Manufacturing Steps
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No additional cost beyond MOF
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HIgh Thermal Stability
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Tolerates all Catheter Manufacturing Processes
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Unchanged Sterilization Processes